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For determination of ACTH in biological fluid the assay method to be used must be highly sensitive as well as specific to this trophic hormone. LIPSCOMB and NELSON described an excellent method to detect a minor amount of ACTH by measuring corticosterone concentration in adrenal venous blood of hypophysectomized rats1). GIRARD and VANCE modified this method and reported that the sensitivity could be further increased by injecting the material into the abdominal aorta at the level of the adrenal artery and one assay rat would be injected several doses of standard and unknown making it possible to calculate the potency of unknown in one rat2). However, the difference of strain and condition in which animals are raised may likely result in different response patterns to exogenous ACTH even if an assay method of identical design is used. The present paper is dealt with the study on the pattern of adrenal corticosterone secretion following intravenous administrations of ACTH U. S. P. and also describes a sensitive method for ACTH using female rats of Wistar strain which are the most commonly used in Japan.

SENSITIVE ASSAY METHOD FOR ACTH USING AN INCREASE IN SECRETION RATE OF ADRENAL VENOUS CORTICOSTERONE IN HYPOPHYSECTOMIZED RATS OF WISTAR STRAIN