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The regulatory mechanism of anaphylactic release of histamine and SRS-A from passively sensitized guinea-pig lung tissue was studied. The release of histamine and SRS-A from sensitized lung tissue was markedly decreased by preincubating with isoproterenol, aminophylline, cyclic AMP•Na and PG E2. While the release of both chemical mediators was increased by preincubating with cyclic GMP•Na and PG F2 alpha, and by preincubating with the mixture of PG E2 and PG F2 alpha (1:9) the release of both chemical mediators was markedly increased comparing with that by preincubating with PG F2 alpha alone.

Anaphylactic Release of Histamine and Slow Reacting Substance of Anaphylaxis (SRS-A) from Guinea-Pig Lung and its Modulation by Prostaglandins