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Streptococcus salivarius subsp. salivarius occasionally causes meningitis associated with iatrogenic or traumatic events. We herein describe a case of meningitis caused by this organism in a patient without any apparent risk factors. In an assay of the patient's cerebrospinal fluid, cross-reaction occurred with Streptococcus pneumoniae antigen-coated latex particles in the Pastorex Meningitis Kit. In the in vitro assays, three of the five clinically isolated S. salivarius strains showed cross-reactions with the kit, indicating that these strains expressed pneumococcal antigen-like antigens. This case shows that meningitis caused by S. salivarius can occur spontaneously and it may sometimes be misdiagnosed as S. pneumoniae infection.

internal medicine

Spontaneous Meningitis Due to &lt;i&gt;Streptococcus salivarius&lt;/i&gt; Subsp. &lt;i&gt;salivarius&lt;/i&gt;: Cross-reaction in an Assay with a Rapid Diagnostic Kit that Detected &lt;i&gt;Streptococcus pneumoniae&lt;/i&gt; Antigens