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Human T-lymphotropic virus type 1 (HTLV-I) causes adult T-cell leukemia/lymphoma (ATLL), and is associated with chronic inflammatory diseases, including inflammatory pulmonary diseases. HTLV-I bZIP factor (HBZ), which is expressed in all adult T-cell leukemia cells, plays a critical role in the development of lymphoma and systemic inflammation. HTLV-I is harbored by CD4(+) T cells that express forkhead box P3 (Foxp3), and HBZ interacts with Foxp3. This study investigated the chest computed tomography (CT) findings and expression of HBZ and Foxp3 in the bronchoalveolar lavage (BAL) cells from patients with HTLV-I-associated lung disorders.

internal medicine

Increased Expression of &lt;i&gt;HBZ&lt;/i&gt; and &lt;i&gt;Foxp3&lt;/i&gt; mRNA in Bronchoalveolar Lavage Cells Taken from Human T-lymphotropic Virus Type 1-associated Lung Disorder Patients