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There is growing interest in the use of transcranial sonography (TCS) of the substantia nigra (SN) in patients with Parkinson's disease (PD), as it has been reported that SN hyperechogenicity may be present in about 90% of PD patients. However, TCS of the SN has not been applied in Japanese patients, and its clinical potential has not been determined.

internal medicine

Transcranial Sonography of the Substantia Nigra in Japanese Patients with Parkinson's Disease or Atypical Parkinsonism: Clinical Potential and Limitations