English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Isolated ACTHdeficiency is well known to be a rare cause of secondary adrenocortical insufficiency. The diagnosis is made by the demonstration of low cortisol production with low plasma ACTH,absent adrenal responses to stimulation for pituitary or hypothalamus with intact adrenal response to exogenous ACTH,and normal secretary indices of other pituitary hormones. It has been frequently reported that some cases with isolated ACTHdeficiency are associated with lymphocytic thyroiditis, suggesting an autoimmuneetiology of isolated ACTH deficiency ( l^t). Moreover, Takao et al recently demonstrated that autoantibodies to a 22-kDa human pituitary cytosolic protein were frequently found to be existed in sera from patients with lymphocytic hypophysitis (73.3%) and isolated ACTH deficiency (77.8%), compared with Hashimoto thyroiditis, Grave's disease and normal control subjects (5). It was also reported that the prevalence of a 22 kDa band of anti-pituitary antibodies was significantly higher in patients with isolated ACTHdeficiency than in the controls (6). Those reports suggest that pituitary autoantibodies could be involved in the pathogenesis of isolated ACTHdeficiency. In this issue of the Journal, Sakai et al described that radiation therapy for brain tumor may induce isolated ACTHdeficiency (9).

Does Radiation Therapy for Brain Tumor Affect Pituitary Function, Resulting in Isolated ACTH Deficiency?