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The gene responsible for hereditary hemochromatosis close to the human leukocyte antigen A locus was previously identified and designated as HFE. This study was performed to evaluate the clinical significance of two mutations, C282Y and H63D of HFE, in Japanese patients with hepatic iron overload.

C282Y and H63D Mutations in the HFE Gene Have No Effect on Iron Overload Disorders in Japan.