English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Despite many advances in the antimicrobial therapy of various infectious diseases, sepsis remains a significant cause of morbidity and mortality in hospitalized patients ( 1-3). The usual clinical course of sepsis progresses from unrecognized infection through a period of clinically apparent infection with signs and symptomsof systemic inflammatory responses to a lifethreatening condition of septic shock and multiple organ failure (4). According to our recent observation in patients with systemic inflammatory response syndrome (SIRS), there were stepwise increases in mortality rates in the progression from sepsis to severe sepsis, and finally septic shock; the mortality rates being 30.6 per cent, 53.3 per cent, and 64.0 per cent, respectively (1). For many years it has been known that early recognition of the systemic inflammatory signs associated with infection and prompt detection of the blood-borne pathogens are mandatory for reducing the mortality of sepsis. In a study on surgical sepsis, Wilson demonstrated that if sepsis was not diagnosed and operated upon aggressively prior to the development of shock or organ failure, the mortality rate rose from 12 per cent to 64 88 per cent (5). In addition, a delayed antibiotic therapy would increase the mortality of sepsis (6). In this issue of Internal Medicine, Dr. Aoki and colleagues (7) present the epidemiology of sepsis patients and practice of their management in a tertiary care teaching hospital in Japan.

Management of Septic Patients without the Consultation Services of Infectious Disease Specialists