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This review presents an analysis of the literature on studies of the salience neural network, the dynamics of neural network formation during ontogenesis of the brain, and salience dysregulation in neurodegenerative and neuropsychiatric disorders. The role of dopaminergic imbalance in the formation of aberrant salience in schizophrenia is considered. Particular attention is paid to the studies of the significance of motivational salience and reward system in the pathogenesis of addictive disorders.

Salience neural network: another tribute to fashion or the key to all doors?