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We used an aCGH mini-chip specific to gastric cancer for endoscopic biopsy specimens of gastric cancer to estimate the systemic disease status of the cancer before treatment. We employed the aCGH mini-chip to examine pretherapeutic endoscopic biopsy specimens of 32 gastric cancer lesions from 31 cases. The accuracy levels of the aCGH mini-chip for gastric cancer biopsy specimens were 44% for lymph node metastasis, 80% for liver metastasis, 76% for peritoneal dissemination, and 68% for invasion depth. The aCGH minichip was applicable for endoscopic gastric cancer biopsy specimens. It may contribute the therapeutic decision making with automatic evaluation of systemic gastric cancer disease status. Abbreviation: aCGH, array-based comparative genomic hybridization

journal of translational medicine and research

The estimation of gastric cancer disease status Using array-based comparative genomic hybridization for endoscopic biopsy specimens: Preliminary experience (CGH for gastric cancer biopsy)