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Topical application of cold applied to the skin can be beneficial particularly after minor trauma such as those resulting from sport. This study evaluates a new product that is designed to deliver a sustained cooling effect to the skin. Volunteer subjects were tested with the Deep Freeze Cold Patch applied to the arm on one day and to the thigh on another occasion. The untreated limb was used as a control. Infrared thermography was used under controlled conditions to image the skin at regular time intervals up to three hours, by briefly peeling the patch away from the skin, followed by rapid replacement to the same area of skin. Significant cooling of the area of skin treated with Deep freeze Cold Patch was objectively shown. Deep Freeze Cold Patch (Mentholatum Co Ltd, UK) is a product designed to produce a cooling effect when applied to the skin. This study has objectively investigated the extent of cooling and the effect of time of application of the Deep Freeze Cold Patch to the skin of healthy volunteers. Earlier studies with the aerosol, and the gel formulations of Deep Freeze (Mentholatum Co Ltd, UK) has shown that these treatments are more acceptable than ice packs applied to the skin, the cooling effects being more gentle and also more sustained.1,2 The aim of this study was to investigate the cooling effect of the new product designed to provide a sustained topical cooling effect when applied to the skin. This study reports the thermal effects from the application of the product Deep Freeze Cold Patch to the forearm and the anterior thigh of human healthy volunteers using infra red thermal imaging. 2. Study design Twelve normal healthy volunteers were recruited to the study. After acclimatisation in a temperature controlled laboratory (23 0 C ±1 o C) for 15 minutes, with both arms and legs exposed. One limb was cooled with the patch and the other left exposed to the ambient to act as a control. The patch measuring 10 x 15cm was applied to the mid anterior forearm on the first test, and to the mid anterior thigh on the second test. The tests on each subject were conducted on different days to avoid any persistent effects from skin cooling that might influence the response. The time duration for application of the patch (tested by a pilot study) was maintained in position for three hours at each site. 3. Experimental conditions All subjects were acclimatised with bare arms and legs in the draught free temperature controlled room at 23°C (± 1°C) for 15 minutes, or until a stable thermal image was obtained. Non contact thermal imaging was performed with an A40 FLIR digital infrared camera calibrated at 30 o C for quantitative temperature measurements. The subject was positioned with both arms placed forwards on a flat surface. The IR focal plane array camera was positioned at 90° from the dorsal surface of the arms and hands. Automatic sequence grabbing of the images was achieved with the special infrared imaging software CTHERM. The process was repeated on a separate day for application to the legs. For this test the subject was seated on a chair, with the camera set vertically above to image both legs simultaneously, both feet on the floor. The patch was applied to one mid thigh, the choice of left or right for the patch application was randomised. During the study, temperature sampling of the area of skin covered by the patch was performed by peeling the patch back (approximately 95%) for infrared imaging measurements and then carefully replaced on exactly the same area of skin. 4. Volunteers & Method 12 volunteers were recruited between the ages of 18 and 55 years,10 males and two females were tested under identical conditions. The ages ranged from 19-30 yrs, the mean of 10 males was 23 yrs, and two females 19, and 21 yrs were included. The mean age of the whole group was 22.5 years. Each volunteer attended on two occasions, with each visit lasting for three hours 30 minutes including acclimatisation to achieve a stable baseline temperature. The test laboratory was air-conditioned at 23 o

Monitoring Cooling Agents Applied to the Skin of Normal Subjects by Quantitative Thermal Imaging