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evaluation of HD adequacy in patients with ESRD who were being maintained on regular HD in a trial to identify the prevalence and causes of inadequate HD among the patients and the impact of HD adequacy on other parameters. DESIGN AND SETTING:PROSPECTIVE STUDY, AT SOHAG UNIVERSITY HOSPITAL IN EGYPT. METHODS All patients in this study were subjected to laboratory investigations including blood urea nitrogen (BUN) (before dialysis and after dialysis), serum albumin, and hemoglobin (Hb) level. • URR = (1 [postdialysis BUN ÷ predialysis BUN]) Kt/V was calculated using the second-generation Daugirdas formula • Single-pool Kt/V = −In (R −0.008 × t) + (4 −3.5 × R)×UF/W, R is the ratio of postdialysis to predialysis BUN; t is the length of a dialysis session in hours; UF is the ultrafiltration volume in liters; and W is the patient’s postdialysis weight in kilograms. RESULTS The results shown that 69,64% of patients had adequate HD (KT\V >1,2),and only 30,36% of patients had indequate HD (KT\V>1,2). CONCLUSION A significant percentage(69,64%) of patients in the HD unit of Sohag University hospital had adequate HD. HD adequacy was influenced by several factors such as duration and frequency of the dialysis session. INTRODUCTION End-stage renal disease (ESRD) causes irreversible, severe kidney failure for which patients require treatment with dialysis or kidney transplantation to survive [1]. It is a major outcome of chronic kidney disease (CKD), with an important effect on the quality of life (QOL) and health resource utilization [2]. Hemodialysis (HD) is one of the main modalities of renal replacement therapy [3]. HD patients still have higher mortality and hospitalization rates, as well as lower QOL, compared with the general population [4]. the adequacy of the dialysis dose has a profound effect on patient morbidity and mortality [5]. To ensure that patients are receiving the prescribed urea clearance, the clinician must regularly monitor and measure the dose delivered. Urea clearance should be measured at least every 8 wk. Examples of acceptable techniques for estimating delivered dose are formal single-pool urea kinetics, urea reduction ratio (URR), and Kt/V natural logarithm formulae. [6]. URR stands for urea reduction ratio, meaning the reduction in urea as a result of dialysis. The URR is one measure of how effectively a dialysis treatment removed waste products

Assessment of Hemodialysis Adequacy in patients with Chronic Kidney Disease in the Hemodialysis Unit at Sohag University Hospital