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Background Hyperglycemia is common and associated with increased morbidity and mortality rates in patients hospitalized with acute coronary syndromes (ACS). We aimed to investigate the association between glycemic state and the hospital outcomes in patients with ACS. Methods We conducted a prospective cohort study on 150 patients admitted to the coronary care unit (CCU) with acute coronary syndrome at Sohag University hospital, and the patients were followed up for one month. We classified participants into three groups according to their glycemic state, group A (euglycemic), group B (hyperglycemia and not known to be diabetic), and group C (hyperglycemia and known to be diabetic). Results We found that, there was no statistically significant difference in the individual hospital outcomes included serious arrhythmia, acute pulmonary edema, cardiogenic shock, recurrent ischemia, heart failure, cerebrovascular stroke (CVS) or all cause deaths between the three groups (p value < 0.05). Multivariate regression analysis of the total all cause outcome after adjustment for confounding factors showed that it was statistically significant higher in hyperglycemic patients (group B+ C) compared to euglycemic patients (group A) (Adjusted OR was 1.79; 95% CI 1.31-3.12; p-value 0.01). Conclusion Admission hyperglycemia in both diabetic and non-diabetic patients has a bad impact on the hospital outcomes in patients presented with ACS. So, strict monitoring of blood glucose levels at admission for all patients presented with ACS, diabetic and non-diabetic patients is required, and tight management of hyperglycemia is mandatory.

Impact of glycemic state on hospital outcome in patients with acute coronary syndrome in sohag university hospitals