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Prof. Dr. E.S. Nofal, Kafr El-Sheikh Univ. ABSTRACT: The use and search for antibiotics derived from plants have been accelerated in recent years. Three plants, used traditionally as medicine and as food additives were collected and extracted with hot water, methanol, diethyl-ether, ethyl acetate and chloroform. The used plants were Solanum incanum, Elettaria cardamomum and Zingiber officinale. The plant extracts were screened for their inhibitory effects on eight bacterial and seven fungal pathogens using agar well diffusion method. It was shown that methanol extract was more effective as compared to hot water, diethyl-ether, ethyl acetate and chloroform extracts. Inhibition zone diameters of the methanol extracts of the used plants ranged from 10 to 29 mm and minimum inhibitory concentrations (MIC) from 50 to 150 μg/ml. No toxicity was found using Artimia salina as test organism. Antitumor activity against Ehrlich ascites carcinoma and Lymphoma cell line was recorded only for S. incanum extract.

ANTIMICROBIAL ACTIVITIES OF SOLANUM INCANUM, ELETTARIA CARDAMOMUM AND ZINGIBER OFFICINALE, USED TRADITIONALLY TO TREAT PATHOGENIC MICROBES