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The rabbit Clostridial enterotoxaemia bloat vaccine has been produced for the first time in Egypt at Anaerobic Department at Veterinary Serum and Vaccines Research Institute .It was found that this vaccine induced efficient immunity when it was injected in two doses (4 weeks interval) as 2ml for adult rabbits and 1ml for offspring as the results of vaccinated rabbit at breeding period was 1 IU/ ml, 3IU/ml, and 1.63 IU/ml by mouse neutralization test, heamolytic inhibition assay, and ELISA respectively. Also it produced a very good protection against the disease for 5 months, so animal could be revaccinated after 5 months from primary vaccination. Also during pregnancy booster dose should be given to increase the maternal antibodies titer against the disease, the results of pregnant dams post booster vaccination were 3IU/ml, 7IU/ml, and 3.74 IU/ml which give passive immunity to the newborn till 4 – 6weeks after birth, the titer was 0.5 IU, 1 IU/ml, and 1.17IU/ml one month post parturition. Introduction Rabbit industry is one of the small live stock industries that play a considerable role in solving the problems of meat shortage in developing countries (Lepas et al,1977). Enteritis in rabbit mainly after weaning is the major cause of economic commercial rabbitaries as it induces sudden death and high mortalities about 27-50% at five to seven weeks of age (Wcharmann and wolff, 1985). Many causes losses in are claimed in induction of enteritis in rabbit as Clostridium spp., Escherichia coli , staphylococcus aureus ,salmonella spp. and Vibrio spp. (HaraKudo et al, 1996). Clostridium spp. are the most important one (Szemeredi et al, 1983) as they adversely affecting rabbit’s industry all over the world (Diab et al., 2003). Enterotoxaemia in rabbits is a multifactorial disease associated with changes in the immature caecum at weaning (Lelkes, 1987). Investigations were conducted on enterotoxaemia outbreaks in

Detection of maternal immunity of enterotoxaemia vaccine of Clostridium perfringens type A in serum of pregnant dams and offspring of rabbit