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Background: A search for methods to prevent infertility in patients receiving chemotherapy including methotrexate is important. Cell therapies with human embryonic and specific adult stem cells have emerged as an alternative management for various diseases. Aim: to study the effect of human umbilical cord derived mononuclear cells transplantation on ovarian dysfunction caused by methotrexate in female rats. Methods: the effect of mono nuclear cells (MNCs) treatment (IV injection once in the tail vein for diabetic rats in a dose of 150 × 10 MNCs cells/rat) on ovary and uterus pathology, malondialdehyde (MDA) level in ovary and follicle stimulating hormone (FSH) level was assessed after methotrexate treatment. Results: Treatment with MNCs in rats pretreated with methotrexate significantly improved all parameters measured (body weight, ratio between ovary and body weight, ratio between uterus and body weight), level of MDA in ovary tissue, FSH and histopathology of ovary and uterus as compared to methotrexate only treated rats. Conclusion: These data indicate that MNCs treatment improved ovarian dysfunction associated with methotrexate therapy.

Effect of Human Umbilical Cord Derived Mononuclear Cells Transplantation on Ovarian Dysfunction Caused by Methotrexate in Female Rats