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Thiosemicarbazones and their metal complexes are very promising compounds which present awide range of pharmacological applications as antimicrobial, antiparasital, and antiviral agents In many circumstances the pharmacological activity of thiosemicarbazones increases upon coordination to metal ions. A new novel copper complex of thiosemicarbazide ligand has been prepared andcharacterized by different physical and chemical methods such as 1H NMR Spectroscopy, IRspectra, elemental analysis, molar conductance, electronic spectra and magnetic susceptibilitiesmeasurements. Copper complex behaves as a neutral tridentate in nature , coordination takesplace via carbonyl oxygen , N(2)H and C=S respectively .Also the study of the effect of gammairradiation on ligand andCu(I) complex using different measurments devices. On the other side, theantibacterial activity of ligand and Cu(I) complex against gram positive (Streptococcus pyogenes) andgram negative( Escherichia coli) bacteria was investigated. The result revealed that Cu( I) complexafter gamma irradiation showed a higher antibacterial activity against gram positive (Streptococcuspyogenes) and gram negative(Escherichia coli) bacteria than the ligand

Preparation, Characterization of Copper Complex and its Biological Activity