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Patients and Methods: During the years 2001-2004, a total number of 28 patients with de novo AML were analyzed by FISH to compare the prognostic impact of certain hematological, clinical parameters and cytogenetic abnormalities on CR rates, disease free interval, and the two years OAS. The number of induction courses and the treatment outcome of dose intensification in the post remission therapy was evaluated. Fifteen AML patients received one course of induction chemotherapy, 8 patients received two courses, and five patients received three induction courses.Results: The CR rate after the first induction course was 54% compared to 21% after the second and third induction courses (p=0.01). Patients who did not achieve CR after the first course of induction had lesser chance to achieve it after second or third courses. While stratification of patients according to hematological data as TLC, blood Hb, number of platelets in peripheral blood and clinical parameters as performance status at presentation failed to predict prognosis, FISH analysis could distinguish three groups of patients. A favorable group of cytogenetic abnormalities including five patients with t (8,21), a second group of unfavorable cytogenetic abnonormalities including 11 patients with trisomy 8 (±8) anomaly, and a third intermediate cytogenetic risk group of 10 patients having no cytogenetic abnormalities. The favorable cytogenetic group conferred significantly higher CR rate, longer disease free interval, longer overall survival, and achieved CR only after one course of induction chemotherapy in comparison with the unfavorable cytogenetic group (P<0.05). Dose intensification in the post remission therapy did not add any survival advantage to patients in this study.

Role of FISH Analysis in The Prediction of Treatatment Outcome in Adult Patiatients with de novo AML