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MANSOURA MEDICAL JOURNAL ABSTRACT Background: Schistosomiasis is a major public health problem in developing countries. Currently, praziquantel (PZQ) is the drug of choice for human schistosomiasis. Isosorbide-5-mononitrate (IS-5-MN) is a nitro compound that is used as an antianginal remedy. It must be enzymatically metabolized to release nitric oxide (NO) to exert its pharmacologic activities. This study evaluates the vasodilator effect of the NO donor IS-5-MN on hepatic bilharzial lesions caused by Schistosoma mansoni, and determines whether the combined use of IS-5-MN and PZQ is synergistic or antagonistic. Methods: Swiss albino female mice (CD I strain) were divided into five groups: (i) non-infected; (ii) infected non-treated; (iii) infected and treated with PZQ, 6 weeks post infection (WPI) in a dose of 500 mg/ kg/day for two successive days; (iv) infected and treated with IS-5-MN from the fourth to the tength WPI 5 days/week in a dose of 10.08 mg/kg; (v) infected and treated with IS-5-MN as group (iv) in addition to PZQ as group (iii). Parasitological, biochemical and histopathological parameters that assess disease severity and morbidity were investigated.

THE HEPATOPROTECTIVE EFFECT OF NITRIC OXIDE ON MURINE SCHISTOSOMIASIS MANSONI