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Brain ischemia is a condition in which there is insufficient blood flow to meet its metabolic demands leading to many functional and structural changes. The cerebellum is considered one of the vulnerable regions for brain ischemia. Melatonin, produced by the pineal gland, has antioxidant, anti-inflammatory and antiapoptotic effects. Therefore, the current study has been performed to evaluate the effect of melatonin administration on induced ischemic reperfusion injury (I/R) in rat cerebellar cortex. Thirty adult male albino rats were used and divided into three groups (10 rats / group). Group A contained the sham-control rats, while group B included I/R rats which were subjected to transient ischemia by ligation of both common carotid arteries simultaneously for 10 minutes and subdivided into 2 subgroups; B1(3 days after I/R) and B2 (one month after I/R). Group C included I/R rats (as in group B) with intraperitoneal melatonin administration (in a dose of 5 mg/ kg) 30 minutes before performing ischemia and one & three hours after release of ligation respectively and also was subdivided into 2 subgroups; C1 (3 days after I/R with melatonin administration) and C2 (one month after I/ R with melatonin administration). The cerebellum was dissected and prepared to be stained with haema-

mansoura medical journal

HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY ON THE EFFECT OF MELATONIN IN RAT CEREBELLAR CORTEX INJURY AFTER TRANSIENT BILATERAL COMMON CAROTID ARTERY LIGATION