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The burden of hepatocellular carcinoma (HCC) has been increasing in Egypt with a doubling in the incidence rate in the past 10 years. This has been attributed to several factors. The aim of this study was to evaluate aflatoxin B 1 (AFB 1 ) in serum of HCC patients as a risk factor compared to their relatives. AFB 1 was determined by a quantitative thin layer chromatography. Results of this study showed that HCC was highly correlated to viral hepatitis C (HCV), viral hepatitis B (HBV) and anti-bilharzial antibodies. However, all patients and their relatives, unexpectedly, showed negative AFB 1 in their blood. It can be concluded that AFB 1 is not necessarily present in all cases of HCC as a predisposing factor and that other factors as viral hepatitis and bilharziasis are more commonly correlated to HCC.

Is Affatoxin B1 A Common Risk Factor for Hepatocellular Carcinoma?