English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: Incidental thyroid lesions carry the risk of being malignant. Hence, they present a potential challenge for clinicians that necessitates careful management. Aim of Study: The aim of this retrospective cohort study was to assess the thyroid incidentalomas detected on fluorine18-Fluorodeoxyglucose Positron Emission Tomography/ Computed Tomography ( 18 F-FDG PET/CT), as well as to determine a maximal standardized uptake value (SUVmax) cutoff that could potentially help in the diagnostic process. Patients and Methods: Medical records of 1526 patients who performed 18 F-FDG PET/CT as part of the diagnostic work up for non-thyroid malignancy were retrospectively reviewed. Patients with thyroid incidentalomas who fulfilled the eligibility criteria were enrolled into the study. The SUVmax of the lesions and the results of histopathological examination were recorded. Receiver-Operating Characteristic (ROC) curve analysis was carried out. Results: Thyroid incidentalomas were detected in 112/1526 patients (7.3%). Of those, only 46 patients (41%) fulfilled the eligibilty criteria. Histopathological examinations [FNAC (n=46), surgery (n=19)] revealed that 11/46 lesions (23.9%) were malignant, whereas 35/46 lesions (76.1%) were benign. The mean SUVmax of malignant lesions (7.05±1.51) was significantly higher than that of benign lesions (3.18±1.74); p=0.001. An SUVmax cutoff value of 5.5 was the most accurate for discriminating between benign and malignant incidentalomas, with 90.91% sensitivity and 82.86% specificity; p=0.001. Conclusion: The incidence of 18 F-FDG-avid thyroid incidentalomas is relatively high among patients who undergo PET/CT as part of the diagnostic work up for non-thyroid malignancy. The SUVmax values are higher in malignant incidentalomas, yet with a noticeable overlap in the values between benign and malignant lesions. An SUVmax cutoff value of 5.5 can potentially be utilized to predict the nature of incidental thyroid lesions. Correspondence to: Dr. Dalia K. Serour, E-Mail: daliakhaled80@yahoo.com

the medical journal of cairo university/the medical journal of cairo university

Fluorine-18-Fluorodeoxyglucose-Avid Thyroid Incidentalomas on Positron Emission Tomography/Computed Tomography in Patients with Non-Thyroid Malignancy: Incidence and Possible Nature