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Background: Bladder cancer is the 2 nd most common site of cancer in Egyptian males (12.7%), compared to other countries, the incidence and mortality rates are high. The ratio of Squamous Cell Carcinoma (SCC) & Urothelial Carcinoma (UC) types showed a shift towards UC. Keratin 17 (K17) is an oncoprotein that has a role in tumor progression. K17 is overexpressed in SCC, triple negative breast cancer & others. Aim of Study: This study aimed to explore the expression of K17 protein in UC in bladder biopsies of Egyptian cases. Also, to correlate K17 expression with the available clinicopathological data of the studied cases. Patients and Methods: This study was carried out on 60 cases of Egyptian bladder UC. Sections of the collected paraffin blocks were performed and applied for Immunohistochemical staining with K17, mouse monoclonal anti-human K17 antibody. Positive K17 cases assessed for intensity staining and distribution of positive stained cells into (mild, moderate and strong) staining results. Results: K17 showed high expression in UC Egyptian patients biopsies (56.7%), strong intensity was found in more than half of positive cases while it was negative in normal urothelium. K17 is more expressed in papillary UC pattern and more related to bad prognosis features as high grade and muscle invasion. Significant association was detected between positive K17 and squamous differentiation in UC cases. All moderate intensity (100%) and majority of strong staining (77.8%) were of papillary UC (p<0.001). In addition, significant association was found between moderate & strong K17 intensity and negative schistosomiasis ovae cases (p=0.003). Conclusion: Our study calls for considering high expression of K17 in UC especially papillary pattern, high grade & muscle invasion. This study also sheds light on significant association of K17 in UC with squamous differentiation & absence of Schistosomiasis.

Keratin 17 Immunohisto chemical Expression and Prognostic Value in Bladder Urothelial Carcinoma