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Background: It is clear that OA is a complex multifactorial disease process involving cartilage catabolism and anabolism. LIPUS may play a potential chondroprotective role in chondro-cyte metabolism; enhance cell proliferation and matrix pro-duction.Aim of Study: Is to investigate the effect of Low Intensity Pulsed Ultrasound (LIPUS) therapy on cartilage repaire in patient with grade 2 or 3 osteoarthritis of the knee.Methods: Subjects were assigned in one pre and post study groupand receive 20 minutes of LIPUS with power 60 mw/cm and frequency 100Hz over the medial tibiofemoral compartment of the knee of both lower limbs and that was 3 times per week for successive three months. The clinical measures were obtained before the first session and after 36th session, using the Musculoskeletal Ultrasound (MSUS) to assess cartilage thickness.Results: There was a significant difference between MSUS before and after LIPUS treatment in left knee with p-value= 0.01. The mean MSUS increased from 1.81 to 2.27 with a difference 0.45 and in right knee with p-value=0.001. The mean MSUS increased from 2.09 to 2.44 with a difference 0.34.Conclusion: LIPUS has a statistical difference over in-creasing cartilage thickness measured by M.S.U.S in patient with mild to moderate knee osteoarthritis.

Feasibility of Low Intensity Pulsed Ultrasound to Improve Cartilaginous Thickness in Osteoarthritic Knee