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Background: Cisplatin has a major nephrotoxic effect. Aim of Study: To evaluate the protective effect of vitamin C against cisplatin-induced nephrotoxicity. Material and Methods: Sixty adult albino rats divided into 5 groups; group I (10 rats; control), group II (10 rats); received single dose of cisplatin 6mg/kg IP. Group III (10 rats); received single dose of cisplatin 6mg/kg IP 6 hours after single dose of oral vitamin C 350mg/kg. Group IV (15 rats); received single dose of cisplatin 2mg/kg/week for 4 weeks IP and subdivided into three subgroups (5 rats each). Group V (15 rats); received single dose of cisplatin 2mg/kg/week for 4 weeks IP 6 hours after single dose of oral vitamin C 350mg/kg and subdivided into three subgroups (5 rats each). Kidneys were dissected and stained by (H&E), Masson's trichrome (MT) and Periodic acid Schiff (PAS) and examined by light microscopy, and fresh tissue taken from group I, IVB and V-C examined by electron microscopy. Results: Our results showed toxic effect of cisplatin on renal glomeruli and proximal tubular lining in group II with improvement in group III, chronic toxicity effect in group IVC in the form of hyaline casts and thickened BM with apparent improvement in group V. Conclusion: We conclude that the vitamin C has a protective effect against cisplatininduced nephrotoxicity.

Effect of Cisplatin on the Kidney of the Albino Rat and Possible Protective Role of Vitamin C