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The pharmacokinetic profile of ceftiofur sodium, a third generation cephalosporin, was studied in both Friesian and buffalo calves following a single intravenous and intramuscular administration of 2.2 mg kg b.wt. in a cross over study with 15-day wash out period. After i.v administration the serum concentration-time curve of ceftiofur sodium was best fitted using two-compartments open model, with distribution half-lives (t1⁄2(α)) of 0.384 and 0.176 h., elimination half-lives (t1⁄2(β)) of 5.047 and 1.607 h., mean residence time (MRT) of 6.926 and 2.072 h., volumes of distribution at steady-state (Vdss) of 0.206 and 0.134 L kg -1 and total body clearance (ClB) of 0.029 and 0.065 L kg -1 h in Friesian and buffalo calves, respectively. Following intramuscular administration, the drug absorbed with half-lives of absorption (t1⁄2(ab)) of 1.010 and 0.217 h., maximum serum concentrations (Cmax) of 5.539 and 9.663 μg ml -1

Comparative pharmacokinetic and renal clearance study of ceftiofur in cross breed Friesian and Buffalo calves