English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

More than a century neurons with hyperstaining and compacted feature, dark neurons, have remained as a controversy in clinical and experimental neuropathology studies. Strictly speaking dark neuron formation is characterized with a series of morphological features and time-course stainability, but what made them quite bizarre is their nonenzymatic fashion of formation and reversibility. These enigmatic features led to emerging a new theory based on metastability of a gellike structure filling the (neuro) cytoplasm. Although based on the gelgel theory some mysterious aspects of dark neurons could be explained, role of receptors and cytoskeleton were not included. In practice, the term dark neuron is often known as the dead or degenerating neuron while in contrast more than 90-99 percent of dark neurons recover after a short period of time. The aim of this review is to give a clear explanation on the morphological features of dark neuron and also provide a theoretical framework in order to bridge between receptorcytoskeleton and dark neuron behavior.

Dark Neurons: A protective mechanism or a mode of death