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Background: Type 1 diabetes mellitus affects lungs due to poor glycemic control. Improvement in both lung function andarchitecture in experimentally-induced lung injury that received exogenous AMSCs by different mechanisms was found.Curcumin has a potent antioxidant and antifibrotic function.Objective: The current study was designed to elucidate the possible ameliorative role of mesenchymal stem cells and curcuminon the lung in experimentally induced type I diabetes by histological and immunohistochemical study.Materials and Methods:Twenty six adult albino rats were divided into five groups: donor, control group, curcumin group andadipose derived mesenchymal stem cell (AMSCs) group. Group II (diabetic group) received a single dose STZ 50 mg/kg/day,group III received STZ and powdered diet supplemented with 0.05% curcumin, group IV received STZ and 1x106 of culturedand labelled rat AMSCs. Lung sections were subjected to histological, morphometric, biochemical and statistical studies.Results: Diabetes induced histological changes in lung in the form of inflammatory changes in bronchiole, a sig increase inthe thickness of interalveolar septa, thickness of the vessels wall, area % of collagen and count CD105+ve cells. Sig decreasein antioxidant activity and sig increase in oxidant enzymes. Sig increase in L-hydroxyproline(L-hyp) level as well STAT andSMAD genes. Administration of curcumin and AMSCs improved sig the previous changes.Conclusion: Diabetes induced lung injuries in rats that was ameliorated by by curcumin, but AMSCs have more pronouncedeffect than curcumin therapy.

The possible ameliorative role of mesenchymal stem cells and curcumin on the lung in experimentally induced type I diabetes: Histological and immunohistochemical study