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Obesity is a cause of health problems due to its strong association to many disorders' incidence as renal disease. This paper aims at estimating the evolution of oxidative stress in response to high fat diet (HFD) and the effect of Commiphora Myrrha resin ethanolic extract (CMEE) on renal MDA, glutathione reductase (GR) activity in kidney and histopathological alterations in renal tissue. Fifty adult Wister albino male rats were weighed from 100-120 g and assigned into five groups each of 10 rats. Rats were fed on a basal diet for 14 weeks (Cr group). Rats were fed on a basal diet and administrated orally CMEE at dose of 500 mg/kg for 14 weeks (CM group). Rats were fed on HFD for 14 weeks (HFD group). Rats were fed on HFD and orally administration of CMEE at dose of 500 mg/kg for 14 weeks (HFD + CM group). Rats were fed on HFD for 8 weeks then stop HFD and fed on a basal diet with oral administration of CMEE at dose of 500 mg/kg bodyweight for another 6 weeks (HFD then normal diet +CM group). MDA level and GR activity were estimated with histopathological examination of renal tissue of rats. A significant increase in MDA level and a significant decrease of GR activity in the HFD rats. Administration of CMEE to HFD rats in groups IV and V decreased significantly MDA level and increased significantly activity of GR enzyme as compared with the HFD group. Moreover, the GR activity reached to normal level in both groups compared in the control group. HFD induced obesity correlated to kidney disorders. CME had the ability to improve oxidative stress induced by HFD.

Ameliorative Effect of Commiphora Myrrha Against Oxidative Stress Induced by High Fat Diet in Rats