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Star anise (Illicium verum) has been used in folk medicine of China, India, and most other Asian countries to treat stomach aches, vomiting, insomnia, dermal inflammation and rheumatic pain as well as a common spice usage. The present study was designed to investigate the possible ameliorating effect of star anise fruit extract against Etoposideinduced nephrotoxicity in rats to prove the evidence of its traditional pharmacological effectiveness. A total of 40 male Wister albino rats were divided randomly into four groups (1 st group was control; 2 nd group was treated with star anise, 3 rd group was received Etoposide, and 4 th group was treated with both star anise and Etoposide. The administration of Etoposide significantly caused elevation in creatinine, blood urea, sodium, potassium and chloride while calcium ions was significantly decrease when compared with control group. Co-treated rat with star anise and Etoposide maintained the levels of the measured some parameters (creatinine, chloride and calcium ions) closer to the normal values while urea, sodium and potassium ions were significantly decrease when compared with Etoposide group. Histopathological evidence, together with observed Ki67-ir, supported the detrimental effect of Etoposide and the ameliorating effect of star anise water extract on renal toxicity. Finally, it could be concluded that star anise has a promising role and it worth to be considered as a natural substance for ameliorating the renal toxicity and injury induced by Etoposide chemotherapy.

Prevention of Etoposide induced kidney toxicity, electrolytes, injury and KI67 alternations in male rats treated with star anise