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Equigan is an androgenic steroid that improves the growth and food conversion in meat producing animals. The present study was performed to determine the ameliorating effect of propolis in the toxicity of the rat testes induced with Equigan. Fourty male albino rat were divided into four groups (10 animals each); the control group includes animals that injected intramuscularly with olive oil. The second group includes rats received propolis. The third group is the experimental group included animals that received intramuscular injections of Equigan. The last group was co-administrated group where rats received Equigan along with propolis. The results suggest that misuse of growth promoter Equigan may contribute to continuous damage of the testicular function and structure that shown a significant increase in nitric oxide (NO), malondialdehyde (MDA), testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) in Equigan group when compared to the control group, these results decrease in co-administrated Equigan with propolis. On the other hand a significant decrease in superoxide dismutase (SOD), catalase, Glutathione (GSH) and total thiol in Equigan group when compared with control group, and a significant increase in co-administrated Equigan with propolis. It was concluded that; propolis has ameliorating role on the biochemical alterations in Equigan induced testicular toxicity in male rat.

Ameliorating effect of propolis extract against equigan induced