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Background: Obesity is a notable health issue. It was estimated that, about 700 million were obese. Some call this trend as the “New World Syndrome”. Aim of the work: To compare between intravenous injections of one to two grams of magnesium sulphate [MgSO4] in patients scheduled for elective laparoscopic sleeve gastrectomy. Patients and methods: It is a multicenter study, which included 800 patients, who were scheduled for elective laparoscopic sleeve gastrectomy under general anesthesia; all patients were randomly grouped into two equal groups [n = 400]. First group for one gram and second group for two grams of MgSO4 over 10 minutes immediately after induction of anesthesia and before starting surgery. Then, all were assessed postoperatively for different variables. Results: The duration of full recovery was significantly shorter, intensive care unit admission and post-operative pain immediately after recover till the end of first 18 hours, was lower in M 2 when compared to M 1 group. Postoperative respiratory depression, nausea and vomiting were significantly decreased. Number of early ambulation was significantly increased, while length of stay was significantly reduced in M 2 group. Intraoperative bleeding and pain after 18 hours showed non-significant difference between both groups. Postoperative bleeding reported in two patients in M 2 group and retuning to operating room again within 6 hours and managed by blood transfusion and surgical laparoscopy. No patients suffered from deep vein thrombosis or any other complications. Conclusion: Adding MgSO4 to general anesthesia in laparoscopic sleeve gastrectomy had beneficial effects which increased by increasing the dose from one to two grams.

The Beneficial Effects of Adding Magnesium Sulphate to General Anesthesia for Laparoscopic Sleeve Gastrectomy