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The effects of laser irradiation on are of great interest, as they allow for the optimization of hyperthermia treatment. Thermal effect of laser radiation is now used routinely in surgery to incise, coagulate, or vaporize tissues. The laser irradiation power is converted into heat in the target volume with resulting coagulative, necrosis, secondary degeneration and atrophy, and tumor shrinkage with minimal damage to surrounding structures [1]. Accordingly, the main purpose of this study is to develop a finite element model to simulate the laser distribution through the tumor tissue and the heat transfer due to this laser irradiation. Also, we studied the effects of varying laser intensity and cooling conditions at the breast surface. This can be achieved by using finite element models using COMSOL Multiphysics (FEM lab) software 1Introduction: Laser radiation is now used routinely to incise, coagulate, or vaporize tissues. The laser light power is converted into heat in the target volume increasing the temperature of the required area causing hyperthermia, secondary degeneration, or tumor shrinkage with minimal damage to surrounding structures [4]. The use of lasers in surgery introduces some desirable features over normal surgical methods such as increased precision, improved homeostasis, and less tissue manipulation. The biological effects of laser energy depend on the laser wavelength, laser power, the duration of irradiance, blood perfusion, and both the optical and thermal properties of the tissue involved. Laser-tissue interaction mechanisms may be thermal, photochemical, or mechanical in nature [5]. Photochemical is like Photo Dynamic Therapy (PDT). Photomechanical like the effects induced using pulsed lasers (photo acoustic, photo disruptive). The surgical procedures that involve coagulation or ablation of tissue are thermal. Laser irradiation works best for cancers that are rapidly or actively dividing, and recent research suggests that it enhances radio sensitivity of dividing cells by enhancing oxygenation of the tumor tissues. This oxygenation is thought to be caused by increased blood perfusion coupled with a decreased oxygen consumption rate due to mild hyperthermia [6,7]. However, further investigation on the use of hyperthermia in conjunction with radiotherapy is necessary to study the effects of this technique on normal tissues as well as to quantify the vessels due to the increase in temperature. The thermal effects of laser energy depend on the laser wavelength, laser power, the duration of irradiance, blood perfusion and both the optical and thermal properties of the tissue

Theoretical and Simulation Studies on Treatment of Breast Cancer using Laser-Induced Photothermal