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Vitiligo is the commonest dyspigmentation disorder of skin and/or mucosa, with clinical manifestations of porcelain white patches. It is considered to be a multifactorial disease caused by the destruction of melanocytes. The aim of this study is to estimate serum S100B level and to evaluate its correlation with vitiligo activity and severity. Sixty three patients had vitiligo and twenty healthy volunteers as control group were included in our study. All cases were assessed for severity by VASI score and the disease activity for the last one year. Serum S100B level was estimated in both patient and control groups. There was a highly statistically significant difference with p-value <0.001 between serum S100B level and vitiligo severity measured by VASI. There was a statistically significant difference with p-value < 0.05 between serum S100B level and vitiligo activity . In Conclusion, Serum S100B level could be used as a biochemical marker for vitiligo activity and severity.

RELATION OF SERUM LEVEL OF S100B WITH VITILIGO ACTIVITY AND SEVERITY.