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Back ground: Alopecia areata is a recurrent, non-scaring type of hair loss considered to be an autoimmune process. Though its etiopathogenesis is not fully understood, many therapeutic options have been used by dermatologists, but none are curative or preventive. Prostaglandins analogues which are used to treat glaucoma. Increase in eye lash number, thickness and pigmentation have been reported as side effect. Methods: This cross sectional case control study was conducted on thirty seven Egyptian patients with alopecia areata including 15 females and 22 males with age ranging from 18 to 45 years old. Eight healthy Egyptian volunteers who had no systemic or dermatological diseases of matching age, sex and BMI served as control. The assessment was performed according to SALT score. Results: There was statistically highly significant difference between the two groups regarding the mean value of PGD2 in tissue in AA patients. It was significantly lower than in control group (p < 0.001). The mean value of PGD2 in serum in AA patients was significantly lower than in control group (p< 0.05). Conclusion: Prostaglandin D2 exhibits a strong role in etiology of alopecia areata and significantly was elevated in serum and tissue of alopecia areata patients.

Estimation of serum prostaglandin D2 levels and its expression in tissue of Alopecia areata