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Neonatal hyperbilirubinemia is a leading cause of morbidity and mortality in developing countries with adverse consequences occur as neonatal mortality, cerebral palsy, isolated auditory impairment, and a diverse manifestation of subtle processing disorders because of bilirubin-induced neurologic dysfunction (BIND). In severe and rapidly increasing jaundice, the use of intensive phototherapy provides greater effectiveness and a faster decrement in bilirubin level. This is a prospective study conducted on 40 neonates with severe hyperbilirubinemia admitted to NICU at Fayoum University Hospital, Faculty of Medicine, Fayoum University, Egypt in the period between April 2017 to October 2017. All newborns are subjected to intensive phototherapy (Bilisphere 360) and BIND score was assessed before and after administration of intensive phototherapy. Our study showed that 55 % of babies were mild BIND, 40% were moderate and only 5% with severe BIND (before bilisphere). While 97.5% became normal BIND and 2.5% were moderate BIND (after bilisphere).

Impact of Intensive Phototherapy on Neurological State of Neonates with Severe Hyperbilirubinemia