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We used in our study Twenty rats ,divided into two  groups .the first group consist of  10 rats considered as a control group, while the second group treated with 0.05 mlbody weightday of dipyron injected for 30 days duration. The  toxic effect of dipyrone was obvious in the different tissue and haematotoxic effects  . The histological changes were obvious in the hepatic cell whichof liver were  characterized by atrophy ,irregular hepatic cells ,RBC cells in the blood sinusoid. However,the spleen tissue contains nodule (white pulpe ).The bony tissue have osteocytes large bony vacuoles and the blood vessel were congested.

Effect of Metamizole (Dipyrone) on Blood and Histological Pictures of Liver and Spleen in Rats