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Background: Multiple myeloma (MM) is heterogeneous malignant neoplasm that occurs mainly in patients over 50 years of age .Detection of monoclonal free light chains (FLCs) is important for diagnosis and monitoring of monoclonal gammopathies. Aim of the Work: this prospective study was done to correlate between K:L ratio and other parameters used in diagnosis for patients with Multiple Myeloma in Egyptian patients. Patients and Methods: twenty eight Egyptian patients with newly diagnosed MM who attend the hematology unit of Ain Shams university hospital and Sheikh Zayed specialized hospital. Results: The study included 28 patients 14 males with percent of 50%and 14 females with percent of 50% .Age: mean=52.46±9.63, Range 28-74. There is statistical significance between K:L ratio and cytogenetics with p-value 0.027. The initial level of K;L ratio affect the response to chemotherapy being higher in poor response patients . Conclusion: K;L ratio is highly sensitive and highly specific test in diagnosis and follow up of MM patients and its use as routine test may aid in the prognostic stratification of newly diagnosed MM patients together with other prognostic parameters .

Study of Kappa to Lambda ratio in Multiple Myeloma as a predictor of outcome and prognostic factor in Egyptian Patients