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Background: Diabetes mellitus is a chronic disorder that can affect the reproductive system leading to fertility dysfunction. The prostate plays an important role in the reproduction and it is a frequent target for diabetic complications. Flaxseed is a promising alternative in many chronic diseases due to its health benefits. It has a proposed role in controlling diabetes due to its wide pharmacological activities.  im: Evaluation of the possible protective role of flaxseed extract on the ventral prostate gland of diabetic rats.  Materials & Methods: Fifty adult male albino rats were used as a control group and experimental group that received a single intra-peritoneal injection of streptozotocin (60 mg/kg). The experimental rats with confirmed diabetes mellitus were subdivided into: diabetic group that kept without treatment and diabetic–flaxseed group (400 mg/kg/day orally). After four weeks, specimens of the ventral prostate lobes were processed for histological and immunohistochemical study using antibodies against Bcl-2, α-smooth muscle actin and androgen receptor. Results: In comparison with the control, specimens of the diabetic group showed glandular epithelial atrophy with thickening of the fibromuscular stroma. Reduced epithelial height and a statistically significant decrease in Bcl2 immunoexpression were observed in the epithelial cells. A statistically significant increase in the collagen fibers and α-SMA immunoexpression was seen in the stroma. Androgen receptor immunoreactivity was significantly decreased in both epithelial and stromal cells. In contrast, minimal changes appeared in diabetic-flaxseed group that received flaxseed extract.  Conclusion: Diabetes induced structural alterations in the ventral prostate gland of rats. Administration of flaxseed extract attenuated these effects and partially preserved the glandular structure.

the egyptian journal of histology

The potential protective role of flaxseed extract on ventral prostate in a rat model of streptozotocin-induced diabetes: A histological and immunohistochemical study