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Hyperprolactinemia (HPRL) commonly causes primary amenorrhea and reproductive disorders. Resveratrol (RES), a natural phenol, possesses antioxidant, anti-inflammatory and anti-apoptotic effects. However, its protective role on the histological structure of female reproductive organs in case of HPRL remains unclear.Aim of the work: This study aimed at evaluating the protective effect of RES against the HPRL induced by metoclopramide in female albino rats.Materials and Methods: Female rats that showed three regular estrus cycles (determined by vaginal smears) were divided into three groups. Group I was the control group. Group II rats were given oral metoclopramide (2 mg/Kg/day) for 28 consecutive days. Group III rats were given oral RES (20 mg/kg/day) for 28 days concurrently with metoclopramide. Serum superoxide anion (O2−), prolactin (PRL), estradiol (E2), progesterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) were assessed, in addition to measurement of tissues tumor necrosis factor-alpha (TNF-α). Sections from uteri, oviducts and ovaries were stained with hematoxylin and eosin and caspase-3 immunohistochemical stain and were subjected to morphometric and statistical studies.Results: Group II showed significant increase in O2−, TNF-α and PRL, with significant decrease in the sex hormones. There were histological alterations in the uteri, oviducts and ovaries, with significant increased caspase-3 immunoexpression compared to the control. While, in group III, there was significant decrease in O2−, TNF-α and PRL, with significant increase in the sex hormones. The uteri, oviducts and ovaries showed minimal changes, with significant reduction in caspase-3 immunoreactivity compared to group II.Conclusion: Administration of resveratrol ameliorates the oxidative stress, inflammation, hormonal assay alterations, histological changes and apoptosis resulted from induced HPRL in female rats.

the egyptian journal of histology

The effectiveness of resveratrol in protection against histological alterations induced by hyperprolactinemia in reproductive organs of female albino rats