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Nanoparticles have been used as effective platforms for treating skin wounds over the last decade. Potential therapeutic effects on wound healing have been demonstrated through metal nanoparticles, notably silver nanoparticles (AgNPs). Solid state synthesis was used in this work for the preparation of AgNPs without using any external chemicals or solvents. In this current work, dextran was used as reducing agent for silver ions and in the same time as stabilizer for the produced nanoparticles. AgNPs is readily synthesized by eco-grinding artlessly for dextran powder, sodium hydroxide beads. The efficacy of dextran as a dual function for the synthesis of AgNPs was assessed by adjusting the utilized concentration of silver nitrate. Ultra-violet visible spectroscopy (Uv-vis), transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential, X-ray diffraction (XRD), field emission scanning electron microscope -dispersive X-ray (FESEM-EDX) are tools for AgNPs characterization. The resulting AgNPs were added to cotton fabrics at different concentrations. The cytotoxicity and antimicrobial activities of the treated fabrics were examined. The findings showed that the spherical shape was confirmed with a reasonable distribution of prepared AgNPs. In addition, the stability of AgNPs has been attained and values greater than -30 mv have been obtained. The findings also revealed that the nanoparticles were effectively distributed onto the surface of fabrics and penetrated into them. The cotton fabrics treated possess superior antimicrobial properties, which are determined by the process of disc diffusion to suppress pathogenic microbes. Furthermore, for human and non-human cell lines, the cell viability of the treated cotton fabrics has no toxicity effect. On that framework, the synthesis of AgNPs with high yield is based on solvent-free is also offered by one pot synthesis of silver nanoparticles that is eco-friendly, low cost, save effort and chemicals.

Chemical synthesis of silver nanoparticles in its solid state: highly efficient antimicrobial cotton fabrics for wound healing properties