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Some new and known substituted 1,2,3,4-tetrahydroacridines incorporated at their position nine with various sulfa drug or thiosemicarbazide moieties were synthesized. Biologically, these compounds were investigated for their antiproliferative activity against human breast cancer (MCF-7) cell line compared to murine fibroblast normal cell line (BALB/3T3). The results were calculated as the IC50 (inhibitory concentration 50%) compared with Cisplatin as control. Furthermore, a docking simulation study was carried out to predict the inhibitory mode of action of the most active compounds.

The Antiproliferative Activity and Molecular Docking studies of some sulfonamides against cancer cell lines compared to normal cells