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Nicotinonitrile skeletons especially those with an amino group at C2 and/or 4,6-diaryl-substitutents have demonstrated a broad range of biological activities, such as antibacterial [1], antifungal[2] antituberculosis [3], antiviral[4], analgesic, and anti-inflammatory effects [5,6]. Furthermore, they have been used as inhibitors of adenosine kinase, topoisomerase [7], anti-proliferative agents that have been used for the treatment of a number of human cancer cell lines [8 10]. The chemical modification of cellulose is done in order to obtain different kinds of cellulosic derivatives that diverse in their physical and chemical features and could be used in several industrial and environmental applications. The poor solubility of cellulose in water and most common organic solvents is the major obstacle for cellulose reactivity and subsequent modification[11,12]. This is due to the intra and intermolecular hydrogen bonds along the polymer chains. The solubility of cellulose sulfonates particularly cellulose tosylate in organic solvents made them suitable key intermediate for selective nucleophilic substitution reactions on C-6 of anhydroglucose unit during cellulose functionalization [13,14]. The broad spectrum antimicrobial properties of amino cellulose as well as their good biocompatibility made them suitable candidate for the design of novel amino cellulose biopolymers through the chemical grafting of cellulose by amino compounds. Recently, there is an increasing interest for the preparation of new amino cellulose derivatives for their potential applications in different research fields, such as anion-exchange resin, selective membranes [12,13], anticoagulants, biosensors, enzyme immobilization in bioassays [14-16], flame retardants[17], and antimicrobial agents [18]. The antimicrobial activity of the modified natural polysaccharides, such as some chitosan Syntheses of New Antimicrobial Cellulose Materials Based 2-((2-aminoethyl)amino)-4-aryl-6-indolylnicotinonitriles

Syntheses of new antimicrobial cellulose materials based 2-((2-aminoethyl)amino)-4-aryl-6-indolylnicotinonitriles