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HE CENTRAL nervous system (CNS) requires the anticipation of a number of neuro-active amino acids and peptides (1) for its normal function. Thus, aminobutyric acid (GABA), glycine, histadine, tyrosine, arginine, taurine, aspartic and glutamic acids, are involved in the synthesis of neurotransmitters neuromodulators, or their neuro-agonists. In particular, glycine is an inhibitory neurotransmitter (1) that is found in mammalian proteins and tissues. Its role primarily appears to involve the inhibition of neuronal activity in the striatum, substantia nigra and cerebellum. Analougously, -aminobutyric acid (GABA) (2) is a constituent of mammalian tissues particularly the brain and spinal cord. It is synthesized in GABA ergic neurons, and interacts with postsynaptic receptors to exert its inhibitory effects.

Synthesis and Investigation of 2-Propylpentanoyl Amino Acid and Dipeptide Conjugates as Novel Anticonvulsants