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Fish diseases are one of the major problems in the fish farm industry especially the bacterial pathogen (Saikia et al., 2017). For the prevention and control of fish diseases, antibiotics were commonly used in aquaculture for prophylaxis (Susmita et al., 2017). Fluoroquinolones are used to control bacterial infections that cause pulmonary, urinary, and digestive-tract diseases in farmed animals (Papich and Riviere, 2001). NFLX is the third generation of fluoroquinolones; and because it is cheap and has broad-spectrum activity against aerobic Gram-negative bacteria with few side effects on fish, it is generally used for management and controls various fish diseases (Holmes et al., 1985). Chemotherapy including antibiotics decrease the normal flora of fish and biological filters and must be used as emergency measures. It may also decrease or prevent the ARTICLE INFO ABSTRACT Article History: Received: Dec. 14, 2020 Accepted: Jan. 23, 2021 Online: Feb. 4, 2021

egyptian journal of aquatic biology and fisheries

Comparative efficiency of the dietary addition of synbiotic "curazol-M" and norfloxacin on the growth performance, body composition, and histological alteration of the Nile tilapia