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The phylum Echinodermata is contains almost 7000 living and 13,000 fossil species in the world’s oceans and possesses 5 classes, namely Crinoidea, Asteroidea, Ophiuroidea, Echinoidea, and Holothuroidea (Pawson, 2007; Zulliger and Lessios, 2010). They are respectively more commonly known as sea stars, sea urchins, sea cucumbers, sea lilies, and feather stars. They inhabit every ocean, in all climate zones and across all ranges of the depth (Uthicke et al., 2009). Sea stars have significant ecological role as essential predators in the structure and function of intertidal and subtidal benthic communities, since they promote heterogeneity ARTICLE INFO ABSTRACT Article History: Received: April 8, 2020 Accepted: April 28, 2020 Online: April 29, 2020

Antimicrobial activity of the sea star (Astropecten spinulosus) collected from the Egyptian Mediterranean Sea, Alexandria