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The continuous demand to develop novel antibiotics is increased to replace the currently ineffective antibiotics and combat infectious diseaseswhich represent one of the main causes of death worldwidecaused by antibiotic resistant pathogens (de Lima Procópio et al. 2012). Actinomycetes, the high GC Gram-positive bacteria, are the most valuable microbial group and have produced about half of the microbial bioactive secondary metabolites. The bioactive compounds of actinomycetes exhibit a wide range of biological activities including antibacterial, antifungal, anticancer, antioxidant, antiparasitic, enzyme inhibitors, and immunosuppressive (Miao and Davies, 2010; Azman et al. 2015). Moreover, actinomycetes degrade the complex substances present in the natural environment and produce many enzymes of industrial interest: protease, lipase, cellulase, amylase, esterase, and Lasparaginase (Usha et al. 2011; He et al. 2012; Yeager et al. 2017). Among actinomycetes, the genus Streptomyces is the primary producer of bioactive compounds, specially antibiotics (Azman et al. 2015). ARTICLE INFO ABSTRACT Article History: Received: Sept. 15, 2020 Accepted: Oct. 4, 2020 Online: Oct. 7, 2020

Isolation and characterization of Streptomyces sp. NMF76 with potential antimicrobial activity from mangrove sediment, Red Sea, Egypt.