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Lake Nasser is one of the longest man-made lakes in the world; it was formed after the construction of Aswan High Dam. Furthermore it considered the fundamental water bank of Egypt; which provides more than 95% of freshwater needs (Ali et al., 2016). The total surface area is 6276 km 2 , 5237 km 2 represents Lake Nasser and 1039 km 2 in the northern part of Sudan is known as Lake Nubia (Heikal, 2010). The lake bank is extremely irregular with several terminal extensions known as khors that is representing about 79% of total lake surface. Khors are the favorite habitat for fish; therefore Khors are important in fish production (El-Shabrawy and Dumont, 2003). Many previous studies investigated the ecology and morphology of Lake Nasser (Latif, 1984; Khalifa et al., 2000; El-Shabrawy, 2014). The Water quality of the Lake Nasser is influenced by many factors such as; water levels, thermal stratification, water circulation and pollutants (El-Shabrawy, 2014). ARTICLE INFO ABSTRACT Article History: Received: June 4, 2020 Accepted: June 30, 2020 Online: July 2020

Physiological and histological alterations in fishes induced by pollution in Lake Nasser and the potential human risk assessment