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Nile tilapia (Oreochromis niloticus) was injected intraperitoneally with types A, D and A+D of Clostridium perfringcns under .controlled laboratory conditions. The biochemical and haematologicai analyses were carried out on the 3rd, 7lJl and I4lh days post injection. The obtained results showed that: 1. Clinically, the infected fish showed loss of appetite, sluggish and erratic swimming, loss of equilibrium and listless. At the site of injection, there was brownish caseous material which easily separated from the muscle. Gills were congested. Internally, the organs were friable and had a generalized hyperemic appearance. 2. Histopathologically. the striated muscle, at the site of injection showed edema and necrosis with leucocytic infiltration. The gills showed sloughing of secondary lamellae and desquamation of the epithelial covering of secondary lamellae. 3. Significantly decreased numbers of erythrocytes were detected after injection with C perfringens type A or D at all periods. Sporadically significant decreases in haemoglobin and haematocrit were found. Other haematologicai indices such as mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration

EFFECT OF CLOSTRIDIUM PERFRINGENS INFECTION ON SOME BIOCHEMICAL, PHYSIOLOGICAL AND PATHOLOGICAL PARAMETERS IN OREOCHROMIS NILOTICUS