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Ciprofloxacin (15 mg/kg body weight), amoxycillin (50 mg/kg body weight) and ampicillin (80 mg/kg b. wt.) administered orally to male sharptooth catfish Glorias gariepimts 3 times, every 72 hours intervals. Plasma samples were taken for three successive days after the last dose the most important results were : t) Plasma glucose levels were significantly elevated in fish administered ciprofloxacin and amoxycillin at the 3 days studied and ampicillin at the 3rd day. In contrast, hypoglycemia observed in the first two days in plasma of C. gariepinus administered ampicillin. 2) Significant hyperproteinaemia was observed in fish groups administered bertfer etpfefkweaein and amoxycillin antibiotics during the three days studied. Ampicillin showed a significant highest value at the second day, while the values at both 1st and 3rd days showed significant lower values. 3) Administratio n of the three antibiotics significantly raised the plasma urea in the three days studied except the 2nd and 3rd days in fish administrated amoxycillin and ampicillin respectively. Also, increased plasma concentrations of uric acid and creatinine in C. gariepinus administered the three antibiotics at the three days studied were recorded. 4) The AST and ALT activities in C. gariepinus administered both ciprofloxacin and amoxycillin antibiotics showed significant higher values at the 3rd day. The slope of rise of AST and ALT activities in both ciprofloxacin and amoxycillin were greater than that of ampicillin that is approximately similar to the control group. So, ciprofloxacin, amoxycillin followed

COMPARATIVE STUDY OF SOME ANTIBIOTICS ON BIOCHEMICAL CHANGES IN PLASMA OF THE SHARPTOOTH CATFISH CLARIAS GARIEPINUS.